There are remarkably few papers in the literature on this topic [conductivity used to monitor enzyme catalysis, at least that I have been able to find that are relevant to the present work). However it is hardly a recent topic, since Henri used the method to measure gelatin hydrolysis by trypsin in 1903! Conductimetry has been widely applied in micro-biosensors, but I have excluded these (with an exception at the end) as they are 'High-Tech'. A recent literature search [07/04/2019] did not reveal any papers after the ones listed here , the latest being 2015. If you know of other publications that are relevant plase let me know. so I can include them.
For an excellent general text on enzyme assays I would like to refer you to the book of this title edited by Robert Eisenthal & Mike Danson
(see Google for online version)
This book contains a chapter written by my PhD supervisor Keith Brocklehurst
I also authored a book 'Molecular Enzymology' with Robert who was a very clever & original guy who devised, by lateral thinking, the Direct Linear Plot for kinetic analysis
Enzyme catalysed reactions measured by conductivity changes
see highlighted paper below
Urease: (this paper is in French)
An interesting, more recent paper, which uses amperometric detection, is:
Electrochemical detection of uric acid using graphite screen-printed electrodes modified with Prussian blue/poly(4-aminosalicylic acid)/Uricase
By: da Cruz, Filipe Soares; Paula, Fernanda de Souza; Franco, Diego Leoni; et al.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY Volume: 806 Pages: 172-179 Published: DEC 1 2017
I have not, as yet, been able to devise a method using conductivity for the assay of uric acid, which is important for the diagnosis of gout.
For a comparison with a modern hand-held bedside clinical analysis system see Abbott i-STAT. An assay set takes just 2 min. This is used in some Emergency Departments for rapid diagnosis/ treatment but has not generally been adopted because of the cost, which is £10-£20 per assay set (about 6-8 tests of different parameters for each chip). The capital cost of the equipment is ca. £7000 - £10000. It typically requires about 100 microlitres of blood per test set (1 chip).
Radiometer & Siemens (amongst others) manufacture high throughput systems for central laboratories, that perform the testing for the whole hospital and often region.
Past Work on this Topic &